Standard
Intraocular pressure
CAV1 · rs10258482
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Intraocular pressure compared to the general population.
A/C
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Intraocular pressure.
C/C
Published research associates this genotype with typical/baseline likelihood of Intraocular pressure — no copies of the reported risk allele.
Source
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma
Hysi PG,
Cheng CY,
Springelkamp H,
Macgregor S,
Bailey JNC,
Wojciechowski R,
Vitart V,
Nag A,
Hewitt AW,
Höhn R,
Venturini C,
Mirshahi A
and 79 more — show all
Ramdas WD,
Thorleifsson G,
Vithana E,
Khor CC,
Stefansson AB,
Liao J,
Haines JL,
Amin N,
Wang YX,
Wild PS,
Ozel AB,
Li JZ,
Fleck BW,
Zeller T,
Staffieri SE,
Teo YY,
Cuellar-Partida G,
Luo X,
Allingham RR,
Richards JE,
Senft A,
Karssen LC,
Zheng Y,
Bellenguez C,
Xu L,
Iglesias AI,
Wilson JF,
Kang JH,
van Leeuwen EM,
Jonsson V,
Thorsteinsdottir U,
Despriet DDG,
Ennis S,
Moroi SE,
Martin NG,
Jansonius NM,
Yazar S,
Tai ES,
Amouyel P,
Kirwan J,
van Koolwijk LME,
Hauser MA,
Jonasson F,
Leo P,
Loomis SJ,
Fogarty R,
Rivadeneira F,
Kearns L,
Lackner KJ,
de Jong PTVM,
Simpson CL,
Pennell CE,
Oostra BA,
Uitterlinden AG,
Saw SM,
Lotery AJ,
Bailey-Wilson JE,
Hofman A,
Vingerling JR,
Maubaret C,
Pfeiffer N,
Wolfs RCW,
Lemij HG,
Young TL,
Pasquale LR,
Delcourt C,
Spector TD,
Klaver CCW,
Small KS,
Burdon KP,
Stefansson K,
Wong TY,
Viswanathan A,
Mackey DA,
Craig JE,
Wiggs JL,
van Duijn CM,
Hammond CJ,
Aung T
Nature genetics · 2014 · PMID 25173106 · open access
Questions about rs10258482
What is rs10258482?
rs10258482 is a single position in the genome, in or near the CAV1 gene. Published research associates it with intraocular pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs10258482 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10258482 come from?
GWAS Catalog, Nat Genet 2014, PMID:25173106. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants