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Leisure-time exercise behaviour

DPY19L1 · rs10252228

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 1,789 Japanese ancestry physically active cases, 12,191 Japanese ancestry physically inactive controls; replicated in 250 Japanese ancestry physically active cases, 1,786 Japanese ancestry physically inactive controls.

The effect Each copy of the G allele shifted the measure 0.027 higher (95% confidence interval 0.018-0.036); p = 2 × 10−9.

How common The G allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 7, band 7p14.2 — between genes, 21 kb from DPY19L1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Leisure-time exercise behaviour — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Leisure-time exercise behaviour.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Leisure-time exercise behaviour compared to the general population.
Source
Genomewide Association Study of Leisure-Time Exercise Behavior in Japanese Adults
Hara M, Hachiya T, Sutoh Y, Matsuo K, Nishida Y, Shimanoe C, Tanaka K, Shimizu A, Ohnaka K, Kawaguchi T, Oze I, Matsuda F
and 27 more — show all
Ito H, Kawai S, Hishida A, Okada R, Sasakabe T, Hirata A, Ibusuki R, Nindita Y, Furusyo N, Ikezaki H, Kuriyama N, Ozaki E, Mikami H, Nakamura Y, Suzuki S, Hosono A, Katsuura-Kamano S, Arisawa K, Kuriki K, Endoh K, Takashima N, Kadota A, Nakatochi M, Momozawa Y, Kubo M, Naito M, Wakai K
Medicine and science in sports and exercise · 2018 · PMID 30102679 · open access

Questions about rs10252228

What is rs10252228?

rs10252228 is a single position in the genome, in or near the DPY19L1 gene. Published research associates it with leisure-time exercise behaviour. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10252228 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10252228 come from?

GWAS Catalog, Med Sci Sports Exerc 2018, PMID:30102679. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Leisure-time exercise behaviour (rs10252228). MyGeneLog™. https://www.mygenelog.com/variants/rs10252228

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