4 474226133125Reads by AI crawlersClaude4ChatGPT2Google · Gemini0Perplexity2Meta AI6Microsoft · Copilot1Amazon3Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others25Total47Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied up to 56,910 European ancestry men, up to 86,570 European ancestry women; replicated in up to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African American/Afro-Caribbean ancestry men, 6,258 African American/Afro-Caribbean ancestry women, 2,285 South Asian ancestry men, 506 South Asian ancestry women, 195 Seychellois ancestry men, 266 Seychellois ancestry women.
The effect
Each copy of the A allele shifted the measure 0.0347 higher (95% confidence interval 0.026-0.043); p = 2 × 10−16.
How common The A allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 7, band 7p15.2 — between genes, 12.3 kb from LOC100506236.
What each result means
A/ATwo copies of the version the research linked to Waist-to-hip ratio adjusted for body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Waist-to-hip ratio adjusted for body mass index. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Waist-to-hip ratio adjusted for body mass index. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs10245353
What is rs10245353?
rs10245353 is a single position in the genome, in or near the NFE2L3 gene. Published research associates it with waist-to-hip ratio adjusted for body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10245353 linked to?
On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution). The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs10245353?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs10245353 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10245353 come from?
GWAS Catalog, Nature 2015, PMID:25673412. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 474226133125Reads by AI crawlersClaude4ChatGPT2Google · Gemini0Perplexity2Meta AI6Microsoft · Copilot1Amazon3Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others25Total47Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Waist-to-hip ratio adjusted for body mass index (rs10245353). MyGeneLog™. https://www.mygenelog.com/variants/rs10245353