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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 96,385 European ancestry individuals (MTAG effective sample size boosted by aortic valve function and stenosis samples).
The effect
Each copy of the G allele shifted the measure 0.0278 higher (95% confidence interval 0.019-0.037); p = 1 × 10−9.
How common The G allele had a frequency of about 57% in the people studied.
Where it sits Chromosome 7, band 7p14.2 — in an intron of DPY19L2P1.
What each result means
A/ANo copy of the version the research linked to Aortic valve peak velocity (MTAG). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Aortic valve peak velocity (MTAG). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Aortic valve peak velocity (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 41419685 · open access
Questions about rs10224131
What is rs10224131?
rs10224131 is a single position in the genome, in or near the DPY19L2P1 gene. Published research associates it with aortic valve peak velocity (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs10224131 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10224131 come from?
GWAS Catalog, Nature genetics 2026, PMID:41419685. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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