Gene Knowledge Graph
UTC
Standard

Aortic stenosis (MTAG)

near FER · rs10223256

Where this position leads

Condition: Aortic Stenosis

rs10223256 Condition: Aortic Stenosis Aortic Stenosis Condition rs10223256 rs10223256 near FER

What the study found

Who was studied 205,483 European ancestry individuals (MTAG effective sample size boosted by aortic valve function samples).

The effect Each copy of the A allele shifted the measure 0.0267 higher (95% confidence interval 0.02-0.033); p = 2 × 10−15.

How common The A allele had a frequency of about 60% in the people studied.

Where it sits Chromosome 5, band 5q21.3 — between genes, 19.2 kb from LINC01023.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Aortic stenosis (MTAG) compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Aortic stenosis (MTAG).
C/C Published research associates this genotype with typical/baseline likelihood of Aortic stenosis (MTAG) — no copies of the reported risk allele.
Source
Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk
Kany S, Rämö JT, Hou C, Jurgens SJ, Khurshid S, Nauffal V, Cunningham JW, Lau ES, Koyama S, Ho JE, Olgin JE, Elmariah S
and 4 more — show all
Palotie A, Lindsay ME, Ellinor PT, Pirruccello JP
FinnGen
Nature genetics · 2026 · PMID 41419685 · open access

Questions about rs10223256

What is rs10223256?

rs10223256 is a single position in the genome, in or near the near FER gene. Published research associates it with aortic stenosis (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10223256 linked to?

On MyGeneLog this position is linked to Aortic Stenosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs10223256 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10223256 come from?

GWAS Catalog, Nature genetics 2026, PMID:41419685. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Aortic stenosis (MTAG) (rs10223256). MyGeneLog™. https://www.mygenelog.com/variants/rs10223256

← See all variants