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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 77,052 European ancestry cases, 378,169 European ancestry controls.
The effect
Each copy of the G allele carried 1.04 times the odds of Osteoarthritis (95% confidence interval 1.02-1.05); p = 2 × 10−8.
How common The G allele had a frequency of about 27% in the people studied.
Where it sits Chromosome 1, band 1q44 — in an intron of KIF26B.
What each result means
G/GTwo copies of the version the research linked to Osteoarthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Osteoarthritis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Osteoarthritis. This is the starting point the study compared everyone against.
Nature genetics · 2019 · PMID 30664745 · open access
Questions about rs10218792
What is rs10218792?
rs10218792 is a single position in the genome, in or near the KIF26B gene. Published research associates it with osteoarthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10218792 linked to?
On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs10218792 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10218792 come from?
GWAS Catalog, Nat Genet 2019, PMID:30664745. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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