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Migraine

PRDM16 · rs10218452

Where this position leads

What the study found

Who was studied 59,674 European ancestry cases, 316,078 European ancestry controls.

The effect Each copy of the G allele carried 1.11 times the odds of Migraine (95% confidence interval 1.10-1.13); p = 5 × 10⁻³⁸.

How common The G allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 1, band 1p36.32 — in an intron of PRDM16.

What each result means

A/A No copy of the version the research linked to Migraine. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Migraine. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Migraine. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH, Farh KH, Cuenca-Leon E, Muona M, Furlotte NA, Kurth T, Ingason A

and 95 more — show all

McMahon G, Ligthart L, Terwindt GM, Kallela M, Freilinger TM, Ran C, Gordon SG, Stam AH, Steinberg S, Borck G, Koiranen M, Quaye L, Adams HH, Lehtimäki T, Sarin AP, Wedenoja J, Hinds DA, Buring JE, Schürks M, Ridker PM, Hrafnsdottir MG, Stefansson H, Ring SM, Hottenga JJ, Penninx BW, Färkkilä M, Artto V, Kaunisto M, Vepsäläinen S, Malik R, Heath AC, Madden PA, Martin NG, Montgomery GW, Kurki MI, Kals M, Mägi R, Pärn K, Hämäläinen E, Huang H, Byrnes AE, Franke L, Huang J, Stergiakouli E, Lee PH, Sandor C, Webber C, Cader Z, Muller-Myhsok B, Schreiber S, Meitinger T, Eriksson JG, Salomaa V, Heikkilä K, Loehrer E, Uitterlinden AG, Hofman A, van Duijn CM, Cherkas L, Pedersen LM, Stubhaug A, Nielsen CS, Männikkö M, Mihailov E, Milani L, Göbel H, Esserlind AL, Christensen AF, Hansen TF, Werge T, Kaprio J, Aromaa AJ, Raitakari O, Ikram MA, Spector T, Järvelin MR, Metspalu A, Kubisch C, Strachan DP, Ferrari MD, Belin AC, Dichgans M, Wessman M, van den Maagdenberg AM, Zwart JA, Boomsma DI, Smith GD, Stefansson K, Eriksson N, Daly MJ, Neale BM, Olesen J, Chasman DI, Nyholt DR, Palotie A

International Headache Genetics Consortium

Nature genetics · 2016 · PMID 27322543

Questions about rs10218452

What is rs10218452?

rs10218452 is a single position in the genome, in or near the PRDM16 gene. Published research associates it with migraine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10218452 linked to?

On MyGeneLog this position is linked to Migraine. The research behind each link, and its sources, are set out on that condition page.

Does having rs10218452 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10218452 come from?

GWAS Catalog, Nat Genet 2016, PMID:27322543. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Migraine (rs10218452). MyGeneLog™. https://www.mygenelog.com/variants/rs10218452

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