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Sensitive

Schizophrenia

SPHKAP · rs10204933

Where this position leads

Condition: Schizophrenia

rs10204933 Condition: Schizophrenia Schizophrenia Condition rs10204933 rs10204933 SPHKAP

What the study found

Who was studied 1,940 Japanese ancestry cases, 7,408 Japanese ancestry controls; replicated in 4,071 Japanese ancestry cases, 54,470 Japanese ancestry controls.

The effect Each copy of the G allele carried 1.30 times the odds of Schizophrenia (95% confidence interval 1.213-1.386); p = 4 × 10−10.

Where it sits Chromosome 2, band 2q36.3 — between genes, 25.2 kb from SPHKAP.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Schizophrenia — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Schizophrenia.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Schizophrenia compared to the general population.
Source
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect
Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A, Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T
and 20 more — show all
Kikuchi M, Kanahara N, Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R, Yoshikawa T, Kubo M, Iwata N
Schizophrenia bulletin · 2019 · PMID 30285260

Questions about rs10204933

What is rs10204933?

rs10204933 is a single position in the genome, in or near the SPHKAP gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10204933 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs10204933 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10204933 come from?

GWAS Catalog, Schizophr Bull 2018, PMID:30285260. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Schizophrenia (rs10204933). MyGeneLog™. https://www.mygenelog.com/variants/rs10204933

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