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Who was studied 2,853 European ancestry cases and 37,405 European ancestry controls; replicated in 1,827 European ancestry cases and 2,181 European ancestry controls.
The effect
Each copy of the C allele carried 1.51 times the odds of Vitiligo (95% confidence interval 1.38-1.66); p = 4 × 10−19.
How common The C allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 2, band 2p16.1 — in a non-coding transcript of PPP4R3B-DT.
What each result means
C/CTwo copies of the version the research linked to Vitiligo. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Vitiligo. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Vitiligo. This is the starting point the study compared everyone against.
Nature genetics · 2016 · PMID 27723757 · open access
Questions about rs10200159
What is rs10200159?
rs10200159 is a single position in the genome, in or near the PPP4R3B gene. Published research associates it with vitiligo. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10200159 linked to?
On MyGeneLog this position is linked to Vitiligo. The research behind each link, and its sources, are set out on that condition page.
Does having rs10200159 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10200159 come from?
GWAS Catalog, Nat Genet 2016, PMID:27723757. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
6 313123220Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI3Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others20Total31Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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