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Inguinal hernia

near EFEMP1 · rs10199082

Where this position leads

Condition: Inguinal Hernia

rs10199082 Condition: Inguinal Hernia Inguinal Hernia Condition rs10199082 rs10199082 near EFEMP1

What the study found

Who was studied 13,047 European ancestry cases, 262,499 European ancestry controls; replicated in 4,450 European ancestry cases, 87,398 European ancestry controls.

The effect The reported allele is C; the catalogue records no effect size ; p = 3 × 10−24.

How common The C allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 2, band 2p16.1 — between genes, 53 kb from EFEMP1.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Inguinal hernia compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Inguinal hernia.
T/T Published research associates this genotype with typical/baseline likelihood of Inguinal hernia — no copies of the reported risk allele.
Source
Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank
Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J
Hernia : the journal of hernias and abdominal wall surgery · 2022 · PMID 34382107

Questions about rs10199082

What is rs10199082?

rs10199082 is a single position in the genome, in or near the near EFEMP1 gene. Published research associates it with inguinal hernia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10199082 linked to?

On MyGeneLog this position is linked to Inguinal Hernia. The research behind each link, and its sources, are set out on that condition page.

Does having rs10199082 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10199082 come from?

GWAS Catalog, Hernia : the journal of hernias and abdominal wall surgery 2022, PMID:34382107. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Inguinal hernia (rs10199082). MyGeneLog™. https://www.mygenelog.com/variants/rs10199082

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