Standard

Body mass index

near NR4A2 · rs10198345

Where this position leads

Conditions: Waist-to-Hip Ratio (Body Fat Distribution), Obesity and Body Weight

What the study found

Who was studied 806,834 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0109 lower (95% confidence interval 0.0074-0.0144); p = 1 × 10⁻⁹.

How common The T allele had a frequency of about 66% in the people studied.

Where it sits Chromosome 2, band 2q24.1 — in an intron of LINC01876.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.

Source

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, Yang J, Jones S

and 10 more — show all

Beaumont R, Croteau-Chonka DC, Winkler TW, Hattersley AT, Loos RJF, Hirschhorn JN, Visscher PM, Frayling TM, Yaghootkar H, Lindgren CM

GIANT Consortium

Human molecular genetics · 2019 · PMID 30239722 · open access

Questions about rs10198345

What is rs10198345?

rs10198345 is a single position in the genome, in or near the near NR4A2 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10198345 linked to?

On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution), Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs10198345 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10198345 come from?

GWAS Catalog, Hum Mol Genet 2018, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs10198345). MyGeneLog™. https://www.mygenelog.com/variants/rs10198345

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