Standard

Prostate-specific antigen levels

near GDF7 · rs10193919

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 85,824 European ancestry individuals, 3,509 African American or Afro-Caribbean individuals, 3,337 East Asian ancestry individuals, 3,098 Hispanic or Latin American individuals.

The effect Each copy of the T allele shifted the measure 0.031 higher (95% confidence interval 0.023-0.039); p = 2 × 10⁻¹⁵.

How common The T allele had a frequency of about 34% in the people studied.

Where it sits Chromosome 2, band 2p24.1 — between genes, 1.8 kb from GDF7.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Prostate-specific antigen levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Prostate-specific antigen levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Prostate-specific antigen levels compared to the general population.

Source

Genetically adjusted PSA levels for prostate cancer screening

Kachuri L, Hoffmann TJ, Jiang Y, Berndt SI, Shelley JP, Schaffer KR, Machiela MJ, Freedman ND, Huang WY, Li SA, Easterlin R, Goodman PJ

and 11 more — show all

Till C, Thompson I, Lilja H, Van Den Eeden SK, Chanock SJ, Haiman CA, Conti DV, Klein RJ, Mosley JD, Graff RE, Witte JS

Nature medicine · 2023 · PMID 37264206 · open access

Questions about rs10193919

What is rs10193919?

rs10193919 is a single position in the genome, in or near the near GDF7 gene. Published research associates it with prostate-specific antigen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10193919 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10193919 come from?

GWAS Catalog, Nature medicine 2023, PMID:37264206. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Prostate-specific antigen levels (rs10193919). MyGeneLog™. https://www.mygenelog.com/variants/rs10193919

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