0 441159122221Reads by AI crawlersClaude0ChatGPT1Google · Gemini1Perplexity5Meta AI9Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others21Total44Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 10,257 European ancestry cases, 470,725 European ancestry controls; replicated in up to 15,126 European ancestry cases, up to 95,725 European ancestry controls.
The effect
Each copy of the T allele carried 1.07 times the odds of Restless legs syndrome (95% confidence interval 1.05-1.11); p = 5 × 10−8.
How common The T allele had a frequency of about 41% in the people studied.
Where it sits Chromosome 2, band 2q32.2 — between genes, 1 kb from SLC40A1.
What each result means
A/ANo copy of the version the research linked to Restless legs syndrome. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Restless legs syndrome. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Restless legs syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
Communications biology · 2020 · PMID 33239738 · open access
Questions about rs10188680
What is rs10188680?
rs10188680 is a single position in the genome, in or near the SLC40A1 gene. Published research associates it with restless legs syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10188680 linked to?
On MyGeneLog this position is linked to Restless Legs Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs10188680 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10188680 come from?
GWAS Catalog, Commun Biol 2020, PMID:33239738. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 441159122221Reads by AI crawlersClaude0ChatGPT1Google · Gemini1Perplexity5Meta AI9Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others21Total44Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Restless legs syndrome (rs10188680). MyGeneLog™. https://www.mygenelog.com/variants/rs10188680