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Body mass index

LRP1B · rs10188429

Where this position leads

Conditions: Childhood Body Mass Index, Obesity and Body Weight

What the study found

Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0165 lower (95% confidence interval 0.013-0.02); p = 1 × 10⁻¹⁶.

Where it sits Chromosome 2, band 2q22.2 — in an intron of LRP1B.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.

G/G Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.

Source

Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures

Jee YH, Wang Y, Jung KJ, Lee JY, Kimm H, Duan R, Price AL, Martin AR, Kraft P

Nature communications · 2025 · PMID 40436827 · open access

Questions about rs10188429

What is rs10188429?

rs10188429 is a single position in the genome, in or near the LRP1B gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10188429 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index, Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs10188429 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10188429 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Body mass index (rs10188429). MyGeneLog™. https://www.mygenelog.com/variants/rs10188429

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