Standard

Uterine fibroids

near REV1 · rs10186340

Where this position leads

Condition: Uterine Fibroids

rs10186340 Condition: Uterine Fibroids Uterine Fibroids Condition rs10186340 rs10186340 near REV1

What the study found

Who was studied 14,905 East Asian ancestry female cases, 69,609 East Asian ancestry female controls, 14,905 Central Asian ancestry female cases, 69,609 Central Asian ancestry female controls, 14,905 South Asian ancestry female cases, 69,609 South Asian ancestry female controls.

The effect Each copy of the A allele shifted the measure 0.0619 lower (95% confidence interval 0.044-0.08); p = 4 × 10−11.

Where it sits Chromosome 2, band 2q11.2 — between genes, 3.2 kb from REV1.

What each result means

A/A Two copies of the version the research linked to Uterine fibroids. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Uterine fibroids. That is a smaller link than two copies.
G/G No copy of the version the research linked to Uterine fibroids. This is the starting point the study compared everyone against.
Source

Questions about rs10186340

What is rs10186340?

rs10186340 is a single position in the genome, in or near the near REV1 gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10186340 linked to?

On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.

Does having rs10186340 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10186340 come from?

GWAS Catalog, Nature communications 2025, PMID:40050615. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Uterine fibroids (rs10186340). MyGeneLog™. https://www.mygenelog.com/variants/rs10186340

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