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Pre-treatment viral load in HIV-1 infection

PPP1CB · rs10182825

What the study found

Who was studied 1,398 European ancestry individuals, 572 Black individuals, 418 Hispanic individuals, 13 Asian ancestry individuals, 39 individuals.

The effect Each copy of the A allele shifted the measure 0.39 lower (95% confidence interval 0.3-0.47); p = 4 × 10−19.

How common The A allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 2, band 2p23.2 — in an intron of SPDYA.

What each result means

A/A Two copies of the version the research linked to Pre-treatment viral load in HIV-1 infection. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Pre-treatment viral load in HIV-1 infection. That is a smaller link than two copies.
G/G No copy of the version the research linked to Pre-treatment viral load in HIV-1 infection. This is the starting point the study compared everyone against.
Source

Questions about rs10182825

What is rs10182825?

rs10182825 is a single position in the genome, in or near the PPP1CB gene. Published research associates it with pre-treatment viral load in hiv-1 infection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10182825 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10182825 come from?

GWAS Catalog, The Journal of infectious diseases 2019, PMID:31219150. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Pre-treatment viral load in HIV-1 infection (rs10182825). MyGeneLog™. https://www.mygenelog.com/variants/rs10182825

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