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Albumin/Globulin ratio in pregnancy

ABCB11 · rs10172795

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁷, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 94,893 Chinese ancestry individuals; replicated in 47,625 Chinese ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0395 higher (95% confidence interval 0.025-0.054); p = 5 × 10⁻⁸.

How common The G allele had a frequency of about 36% in the people studied.

What each result means

A/A No copy of the version the research linked to Albumin/Globulin ratio in pregnancy. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Albumin/Globulin ratio in pregnancy. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Albumin/Globulin ratio in pregnancy. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association analyses of gestational phenotypes identify context-specific genetic effects

Liu S, Zheng H, Gu Y, Yang Z, Zhen J, Wei Y, Liu Y, Chen Y, Wan Z, Guo X, Hu L, Chen X

and 11 more — show all

Li X, Qiu X, Huang S, Chen GB, Hu Z, Namba S, Kanai M, Matsuda K, Okada Y, Zhang Q, Wei F

Nature genetics · 2026 · PMID 42509370

Questions about rs10172795

What is rs10172795?

rs10172795 is a single position in the genome, in or near the ABCB11 gene. Published research associates it with albumin/globulin ratio in pregnancy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10172795 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10172795 come from?

GWAS Catalog, Nature genetics 2026, PMID:42509370. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Albumin/Globulin ratio in pregnancy (rs10172795). MyGeneLog™. https://www.mygenelog.com/variants/rs10172795

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