Sensitive

Coronary heart disease in type 2 diabetes

PDE1A · rs10171703

Where this position leads

What the study found

Who was studied 2,517 Southern Han Chinese ancestry cases, 6,424 Southern Han Chinese ancestry controls; replicated in 1,079 Southern Han Chinese ancestry cases, 2,474 Southern Han Chinese ancestry controls, 764 European ancestry cases, 4,276 European ancestry controls.

The effect Each copy of the C allele carried 1.21 times the odds of Coronary heart disease in type 2 diabetes (95% confidence interval 1.13-1.3); p = 2 × 10⁻⁸.

How common The C allele had a frequency of about 76% in the people studied.

Where it sits Chromosome 2, band 2q32.1 — in an intron of PDE1A.

What each result means

C/C Two copies of the version the research linked to Coronary heart disease in type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Coronary heart disease in type 2 diabetes. That is a smaller link than two copies.

T/T No copy of the version the research linked to Coronary heart disease in type 2 diabetes. This is the starting point the study compared everyone against.

Source

Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes

Tam CHT, Lim CKP, Luk AOY, Shi M, Man Cheung H, Ng ACW, Lee HM, Lau ESH, Fan B, Jiang G, Kong APS, Ozaki R

and 34 more — show all

Chow EYK, Lee KF, Siu SC, Hui G, Tsang CC, Lau KP, Leung JYY, Cheung EYN, Tsang MW, Kam G, Lau IT, Li JKY, Yeung VTF, Lau E, Lo S, Fung S, Cheng YL, Chow CC, Fan X, Chan TF, Yip KYL, Lok S, Yu W, Tsui SKW, Lan HY, Szeto CC, Tang NLS, Tomlinson B, Huang Y, Jenkins AJ, Keech A, So WY, Chan JCN, Ma RCW

Hong Kong Diabetes Biobank Study Group, FIELD Study Investigators · TRansomics ANalysis of Complications and ENdpoints in Diabetes (TRANSCEND) Consortium

Diabetes care · 2023 · PMID 37125963 · open access

Questions about rs10171703

What is rs10171703?

rs10171703 is a single position in the genome, in or near the PDE1A gene. Published research associates it with coronary heart disease in type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10171703 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs10171703 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10171703 come from?

GWAS Catalog, Diabetes care 2023, PMID:37125963. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Coronary heart disease in type 2 diabetes (rs10171703). MyGeneLog™. https://www.mygenelog.com/variants/rs10171703

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