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Menstruation quality of life impact (dysmenorrhea)

IL1A* · rs10167914

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 3,573 Japanese ancestry female cases, 2,161 Japanese ancestry female controls; replicated in 3,580 Japanese ancestry female cases, 2,034 Japanese ancestry female controls.

The effect Each copy of the G allele shifted the measure 0.228 lower (95% confidence interval 0.16-0.29); p = 3 × 10⁻¹².

How common The G allele had a frequency of about 74% in the people studied.

Where it sits Chromosome 2, band 2q14.1 — between genes, 11.3 kb from LOC124907871.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Menstruation quality of life impact (dysmenorrhea) — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Menstruation quality of life impact (dysmenorrhea).

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Menstruation quality of life impact (dysmenorrhea) compared to the general population.

Source

Japanese GWAS identifies variants for bust-size, dysmenorrhea, and menstrual fever that are eQTLs for relevant protein-coding or long non-coding RNAs

Hirata T, Koga K, Johnson TA, Morino R, Nakazono K, Kamitsuji S, Akita M, Kawajiri M, Kami A, Hoshi Y, Tada A, Ishikawa K

and 6 more — show all

Hine M, Kobayashi M, Kurume N, Fujii T, Kamatani N, Osuga Y

Scientific reports · 2018 · PMID 29855537 · open access

Questions about rs10167914

What is rs10167914?

rs10167914 is a single position in the genome, in or near the IL1A* gene. Published research associates it with menstruation quality of life impact (dysmenorrhea). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10167914 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10167914 come from?

GWAS Catalog, Sci Rep 2018, PMID:29855537. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Menstruation quality of life impact (dysmenorrhea) (rs10167914). MyGeneLog™. https://www.mygenelog.com/variants/rs10167914

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