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Skin pigmentation (conditioned on rs1426654 and rs35397)

GRM5 · rs10160510

What the study found

Who was studied 1,047 Hispanic/Latin American individuals, 684 Cape Verdian individuals, 373 African American individuals.

The effect Each copy of the T allele shifted the measure 0.248 lower (95% confidence interval 0.17-0.33); p = 3 × 10−10.

Where it sits Chromosome 11, band 11q14.3 — in an intron of GRM5.

What each result means

A/A No copy of the version the research linked to Skin pigmentation (conditioned on rs1426654 and rs35397). This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to Skin pigmentation (conditioned on rs1426654 and rs35397). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Skin pigmentation (conditioned on rs1426654 and rs35397). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs10160510

What is rs10160510?

rs10160510 is a single position in the genome, in or near the GRM5 gene. Published research associates it with skin pigmentation (conditioned on rs1426654 and rs35397). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10160510 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10160510 come from?

GWAS Catalog, BMC genetics 2019, PMID:31315583. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Skin pigmentation (conditioned on rs1426654 and rs35397) (rs10160510). MyGeneLog™. https://www.mygenelog.com/variants/rs10160510

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