Standard

Cholesteryl esters to total lipids ratio in medium HDL

USP1 · rs10158897

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0606 higher (95% confidence interval 0.052-0.069); p = 2 × 10⁻⁴⁷.

How common The T allele had a frequency of about 33% in the people studied.

Where it sits Chromosome 1, band 1p31.3 — in an intron of USP1.

What each result means

C/C No copy of the version the research linked to Cholesteryl esters to total lipids ratio in medium HDL. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Cholesteryl esters to total lipids ratio in medium HDL. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Cholesteryl esters to total lipids ratio in medium HDL. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide characterization of circulating metabolic biomarkers

Karjalainen MK, Karthikeyan S, Oliver-Williams C, Sliz E, Allara E, Fung WT, Surendran P, Zhang W, Jousilahti P, Kristiansson K, Salomaa V, Goodwin M

and 75 more — show all

Hughes DA, Boehnke M, Fernandes Silva L, Yin X, Mahajan A, Neville MJ, van Zuydam NR, de Mutsert R, Li-Gao R, Mook-Kanamori DO, Demirkan A, Liu J, Noordam R, Trompet S, Chen Z, Kartsonaki C, Li L, Lin K, Hagenbeek FA, Hottenga JJ, Pool R, Ikram MA, van Meurs J, Haller T, Milaneschi Y, Kähönen M, Mishra PP, Joshi PK, Macdonald-Dunlop E, Mangino M, Zierer J, Acar IE, Hoyng CB, Lechanteur YTE, Franke L, Kurilshikov A, Zhernakova A, Beekman M, van den Akker EB, Kolcic I, Polasek O, Rudan I, Gieger C, Waldenberger M, Asselbergs FW, Hayward C, Fu J, den Hollander AI, Menni C, Spector TD, Wilson JF, Lehtimäki T, Raitakari OT, Penninx BWJH, Esko T, Walters RG, Jukema JW, Sattar N, Ghanbari M, Willems van Dijk K, Karpe F, McCarthy MI, Laakso M, Järvelin MR, Timpson NJ, Perola M, Kooner JS, Chambers JC, van Duijn C, Slagboom PE, Boomsma DI, Danesh J, Ala-Korpela M, Butterworth AS, Kettunen J

China Kadoorie Biobank Collaborative Group · Estonian Biobank Research Team · FinnGen

Nature · 2024 · PMID 38448586 · open access

Questions about rs10158897

What is rs10158897?

rs10158897 is a single position in the genome, in or near the USP1 gene. Published research associates it with cholesteryl esters to total lipids ratio in medium hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10158897 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10158897 come from?

GWAS Catalog, Nature 2024, PMID:38448586. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cholesteryl esters to total lipids ratio in medium HDL (rs10158897). MyGeneLog™. https://www.mygenelog.com/variants/rs10158897

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