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Sex hormone-binding globulin levels

ACTG1 · rs10153315

What the study found

Who was studied 370,125 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.00798 higher (95% confidence interval 0.0062-0.0098); p = 6 × 10−20.

How common The T allele had a frequency of about 58% in the people studied.

Where it sits Chromosome 17, band 17q25.3 — in the 5′ untranslated region of ACTG1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Sex hormone-binding globulin levels — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Sex hormone-binding globulin levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Sex hormone-binding globulin levels compared to the general population.
Source

Questions about rs10153315

What is rs10153315?

rs10153315 is a single position in the genome, in or near the ACTG1 gene. Published research associates it with sex hormone-binding globulin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10153315 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10153315 come from?

GWAS Catalog, Nature medicine 2020, PMID:32042192. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Sex hormone-binding globulin levels (rs10153315). MyGeneLog™. https://www.mygenelog.com/variants/rs10153315

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