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Central corneal thickness (MTAG)

MIPOL1 · rs10137741

Where this position leads

Condition: Central Corneal Thickness

rs10137741 Condition: Central Corneal Thickness Central Corneal Thickness Condition rs10137741 rs10137741 MIPOL1

What the study found

Who was studied 17,803 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 2.1 lower (95% confidence interval 1.6-2.61); p = 5 × 10−16.

How common The T allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 14, band 14q13.3 — in an intron of MIPOL1.

What each result means

C/C No copy of the version the research linked to Central corneal thickness (MTAG). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Central corneal thickness (MTAG). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Central corneal thickness (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs10137741

What is rs10137741?

rs10137741 is a single position in the genome, in or near the MIPOL1 gene. Published research associates it with central corneal thickness (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10137741 linked to?

On MyGeneLog this position is linked to Central Corneal Thickness. The research behind each link, and its sources, are set out on that condition page.

Does having rs10137741 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10137741 come from?

GWAS Catalog, JAMA ophthalmology 2022, PMID:35446358. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Central corneal thickness (MTAG) (rs10137741). MyGeneLog™. https://www.mygenelog.com/variants/rs10137741

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