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Who was studied 11,320 European ancestry cases, 47,023 European ancestry controls; replicated in 3,248 European ancestry cases, 197,724 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.113 higher (95% confidence interval 0.082-0.144); p = 9 × 10−13.
Where it sits Chromosome 9, band 9q33.1 — in an intron of DELEC1.
What each result means
C/CNo copy of the version the research linked to Dupuytren's disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Dupuytren's disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Dupuytren's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 38172110 · open access
Questions about rs10125663
What is rs10125663?
rs10125663 is a single position in the genome, in or near the DELEC1 gene. Published research associates it with dupuytren's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10125663 linked to?
On MyGeneLog this position is linked to Dupuytren's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs10125663 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10125663 come from?
GWAS Catalog, Nature communications 2024, PMID:38172110. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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