0 312Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others2Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 7,520 East Asian ancestry female cases, 13,412 East Asian ancestry female controls, 69,501 European ancestry female cases, 100,594 European ancestry female controls, 9,279 African ancestry female cases, 17,358 African ancestry female controls.
The effect
Each copy of the C allele carried 1.06 times the odds of Estrogen-receptor positive breast cancer (95% confidence interval 1.04-1.08); p = 3 × 10−8.
How common The C allele had a frequency of about 9% in the people studied.
Where it sits Chromosome 9, band 9q22.32 — between genes, 83.2 kb from PTCH1.
What each result means
C/CTwo copies of the version the research linked to Estrogen-receptor positive breast cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Estrogen-receptor positive breast cancer. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Estrogen-receptor positive breast cancer. This is the starting point the study compared everyone against.
rs10120432 is a single position in the genome, in or near the near PTCH1 gene. Published research associates it with estrogen-receptor positive breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10120432 linked to?
On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs10120432 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10120432 come from?
GWAS Catalog, Nature genetics 2025, PMID:39753771. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 312Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others2Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Estrogen-receptor positive breast cancer (rs10120432). MyGeneLog™. https://www.mygenelog.com/variants/rs10120432