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Medication use (thyroid preparations)

SLC25A37 · rs10098103

Where this position leads

Condition: Colon Polyp

rs10098103 Condition: Colon Polyp Colon Polyp Condition rs10098103 rs10098103 SLC25A37

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−9, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 24,832 European ancestry cases, 280,750 European ancestry controls, 3,103 East Asian ancestry cases, 175,623 East Asian ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0595 lower (95% confidence interval 0.04-0.079); p = 2 × 10−9.

Where it sits Chromosome 8, band 8p21.2 — in an intron of SLC25A37.

What each result means

C/C Two copies of the version the research linked to Medication use (thyroid preparations). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Medication use (thyroid preparations). That is a smaller link than two copies.
T/T No copy of the version the research linked to Medication use (thyroid preparations). This is the starting point the study compared everyone against.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs10098103

What is rs10098103?

rs10098103 is a single position in the genome, in or near the SLC25A37 gene. Published research associates it with medication use (thyroid preparations). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10098103 linked to?

On MyGeneLog this position is linked to Colon Polyp. The research behind each link, and its sources, are set out on that condition page.

Does having rs10098103 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10098103 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Medication use (thyroid preparations) (rs10098103). MyGeneLog™. https://www.mygenelog.com/variants/rs10098103

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