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QT interval

YPEL2 · rs1009674

Where this position leads

Condition: QT Interval and Drug-Induced Long QT

rs1009674 Condition: QT Interval and Drug-Induced Long QT QT Interval and Drug-Induced Long QT Condition rs1009674 rs1009674 YPEL2

What the study found

Who was studied 52,107 European ancestry individuals; replicated in 48,997 individuals.

The effect Each copy of the T allele shifted the measure 0.57 lower (95% confidence interval 0.43-0.71); p = 2 × 10−15.

How common The T allele had a frequency of about 52% in the people studied.

Where it sits Chromosome 17, band 17q22 — in an intron of YPEL2.

What each result means

C/C No copy of the version the research linked to QT interval. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to QT interval. That is a smaller link than two copies.
T/T Two copies of the version the research linked to QT interval. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1009674

What is rs1009674?

rs1009674 is a single position in the genome, in or near the YPEL2 gene. Published research associates it with qt interval. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1009674 linked to?

On MyGeneLog this position is linked to QT Interval and Drug-Induced Long QT. The research behind each link, and its sources, are set out on that condition page.

Does having rs1009674 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1009674 come from?

GWAS Catalog, Human molecular genetics 2021, PMID:34274964. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

QT interval (rs1009674). MyGeneLog™. https://www.mygenelog.com/variants/rs1009674

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