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Its strongest genetic-study result is p = 10−74, with 14 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 5,107 European ancestry cases, 8,845 European ancestry controls; replicated in 6,076 cases, 7,555 controls.
The effect
Each copy of the T allele carried 1.15 times the odds of Pancreatic cancer (95% confidence interval 1.10-1.20); p = 3 × 10−9.
How common The T allele had a frequency of about 35% in the people studied.
Where it sits Chromosome 8, band 8q24.21 — in an intron of CASC11.
What each result means
A/ANo copy of the version the research linked to Pancreatic cancer. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Pancreatic cancer. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Pancreatic cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Newly curated by the GWAS Catalog: 141 associations across 1 trait ("Bladder cancer"), from Prokunina-Olsson L, et al. in Nature Communications, 2026. Sample in the catalogue's record: 30,156 cases and 1,527,568 controls. Of its 70 positions, 33 already have pages here — 16 on the Bladder Cancer page; 1 on the Lung Cancer page; 1 on the Ulcerative Colitis page — including rs2294008 (PSCA), rs10094872 (MYC), rs2242652 (TERT). Put together by code from the catalogue's records; for anything more, follow the link to the paper. PMID:42706231.
Questions about rs10094872
What is rs10094872?
rs10094872 is a single position in the genome, in or near the MYC gene. Published research associates it with pancreatic cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10094872 linked to?
On MyGeneLog this position is linked to Pancreatic Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs10094872 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10094872 come from?
GWAS Catalog, Oncotarget 2016, PMID:27579533. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 4222213123224Reads by AI crawlersClaude2ChatGPT2Google · Gemini2Perplexity1Meta AI3Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others24Total42Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Pancreatic cancer (rs10094872). MyGeneLog™. https://www.mygenelog.com/variants/rs10094872