Sensitive

Prostate cancer

PCAT1 · rs10086908

Where this position leads

What the study found

Who was studied 5,088 Japanese ancestry cases, 10,682 Japanese ancestry controls; replicated in 4,818 Japanese ancestry cases, 73,261 Japanese ancestry controls.

The effect The reported allele is T; the catalogue records no effect size ; p = 7 × 10⁻¹⁴.

How common The T allele had a frequency of about 80% in the people studied.

Where it sits Chromosome 8, band 8q24.21 — in an intron of PCAT1.

What each result means

C/C No copy of the version the research linked to Prostate cancer. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Prostate cancer. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Prostate cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population

Takata R, Takahashi A, Fujita M, Momozawa Y, Saunders EJ, Yamada H, Maejima K, Nakano K, Nishida Y, Hishida A, Matsuo K, Wakai K

and 19 more — show all

Yamaji T, Sawada N, Iwasaki M, Tsugane S, Sasaki M, Shimizu A, Tanno K, Minegishi N, Suzuki K, Matsuda K, Kubo M, Inazawa J, Egawa S, Haiman CA, Ogawa O, Obara W, Kamatani Y, Akamatsu S, Nakagawa H

Nature communications · 2019 · PMID 31562322 · open access

Questions about rs10086908

What is rs10086908?

rs10086908 is a single position in the genome, in or near the PCAT1 gene. Published research associates it with prostate cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10086908 linked to?

On MyGeneLog this position is linked to Prostate Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs10086908 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10086908 come from?

GWAS Catalog, Nature communications 2019, PMID:31562322. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Prostate cancer (rs10086908). MyGeneLog™. https://www.mygenelog.com/variants/rs10086908

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