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Who was studied 329,821 European ancestry individuals; replicated in 122,867 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 6.44 higher; p = 1 × 10−10.
How common The A allele had a frequency of about 23% in the people studied.
Where it sits Chromosome 5, band 5q21.3 — between genes, 13.2 kb from FBXL17.
What each result means
A/ATwo copies of the version the research linked to Neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Neuroticism. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Neuroticism. This is the starting point the study compared everyone against.
rs10078397 is a single position in the genome, in or near the near FBXL17 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10078397 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
Does having rs10078397 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10078397 come from?
GWAS Catalog, Nature genetics 2018, PMID:29255261. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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