5 1812312Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3Others12Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 10,254 Han Chinese ancestry cases, 10,914 Han Chinese ancestry controls.
The effect
The reported allele is A; the catalogue records no effect size
; p = 3 × 10−30.
How common The A allele had a frequency of about 51% in the people studied.
Where it sits Chromosome 5, band 5p13.1 — in an intron of PRKAA1.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gastric cancer compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gastric cancer.
G/GPublished research associates this genotype with typical/baseline likelihood of Gastric cancer — no copies of the reported risk allele.
rs10074991 is a single position in the genome, in or near the PRKAA1 gene. Published research associates it with gastric cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10074991 linked to?
On MyGeneLog this position is linked to Non-Cardia Gastric Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs10074991 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10074991 come from?
GWAS Catalog, The Lancet. Oncology 2020, PMID:33002439. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
5 1812312Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3Others12Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Gastric cancer (rs10074991). MyGeneLog™. https://www.mygenelog.com/variants/rs10074991