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Corneal structure

LPAR1 · rs1007000

Where this position leads

Condition: Central Corneal Thickness

rs1007000 Condition: Central Corneal Thickness Central Corneal Thickness Condition rs1007000 rs1007000 LPAR1

What the study found

Who was studied 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.07 higher (95% confidence interval 0.031-0.109); p = 5 × 10−12.

How common The T allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 9, band 9q31.3 — in an intron of LPAR1.

What each result means

C/C No copy of the version the research linked to Corneal structure. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Corneal structure. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Corneal structure. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1007000

What is rs1007000?

rs1007000 is a single position in the genome, in or near the LPAR1 gene. Published research associates it with corneal structure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1007000 linked to?

On MyGeneLog this position is linked to Central Corneal Thickness. The research behind each link, and its sources, are set out on that condition page.

Does having rs1007000 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1007000 come from?

GWAS Catalog, Nat Genet 2013, PMID:23291589. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Corneal structure (rs1007000). MyGeneLog™. https://www.mygenelog.com/variants/rs1007000

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