Gene Knowledge Graph
UTC
Standard

Gamma glutamyl transpeptidase

SH3PXD2B · rs10067250

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 344,104 European ancestry individuals, 133,471 East Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0123 lower (95% confidence interval 0.0084-0.0162); p = 3 × 10−10.

Where it sits Chromosome 5, band 5q35.1 — in an intron of SH3PXD2B.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gamma glutamyl transpeptidase compared to the general population.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gamma glutamyl transpeptidase.
G/G Published research associates this genotype with typical/baseline likelihood of Gamma glutamyl transpeptidase — no copies of the reported risk allele.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs10067250

What is rs10067250?

rs10067250 is a single position in the genome, in or near the SH3PXD2B gene. Published research associates it with gamma glutamyl transpeptidase. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10067250 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10067250 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gamma glutamyl transpeptidase (rs10067250). MyGeneLog™. https://www.mygenelog.com/variants/rs10067250

← See all variants