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Waist-hip ratio

HMBS · rs1006195

Where this position leads

Condition: Waist-to-Hip Ratio (Body Fat Distribution)

What the study found

Who was studied 381,152 European female individuals.

The effect Each copy of the T allele shifted the measure 0.0139 higher (95% confidence interval 0.01-0.017); p = 3 × 10⁻¹⁴.

How common The T allele had a frequency of about 39% in the people studied.

Where it sits Chromosome 11, band 11q23.3 — in an intron of HMBS.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2021-06-19. ClinVar record 1246575 NM_000190.4(HMBS):c.34-96G>T

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

G/G No copy of the version the research linked to Waist-hip ratio. This is the starting point the study compared everyone against.

G/T One copy of the version the research linked to Waist-hip ratio. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Waist-hip ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, Yang J, Jones S

and 10 more — show all

Beaumont R, Croteau-Chonka DC, Winkler TW, Hattersley AT, Loos RJF, Hirschhorn JN, Visscher PM, Frayling TM, Yaghootkar H, Lindgren CM

GIANT Consortium

Human molecular genetics · 2019 · PMID 30239722 · open access

Questions about rs1006195

What is rs1006195?

rs1006195 is a single position in the genome, in or near the HMBS gene. Published research associates it with waist-hip ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1006195 linked to?

On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution). The research behind each link, and its sources, are set out on that condition page.

Does having rs1006195 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1006195 come from?

GWAS Catalog, Human molecular genetics 2019, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Waist-hip ratio (rs1006195). MyGeneLog™. https://www.mygenelog.com/variants/rs1006195

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