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Sex hormone-binding globulin levels

FOXN3 · rs1005421

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 370,125 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.00753 higher (95% confidence interval 0.0057-0.0094); p = 4 × 10⁻¹⁷.

How common The C allele had a frequency of about 58% in the people studied.

Where it sits Chromosome 14, band 14q32.11 — in an intron of FOXN3.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Sex hormone-binding globulin levels compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Sex hormone-binding globulin levels.

T/T Published research associates this genotype with typical/baseline likelihood of Sex hormone-binding globulin levels — no copies of the reported risk allele.

Source

Using human genetics to understand the disease impacts of testosterone in men and women

Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, Erzurumluoglu AM, Hollis B

and 10 more — show all

O'Mara TA, McCarthy MI, Langenberg C, Easton DF, Wareham NJ, Burgess S, Murray A, Ong KK, Frayling TM, Perry JRB

Endometrial Cancer Association Consortium

Nature medicine · 2020 · PMID 32042192 · open access

Questions about rs1005421

What is rs1005421?

rs1005421 is a single position in the genome, in or near the FOXN3 gene. Published research associates it with sex hormone-binding globulin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1005421 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1005421 come from?

GWAS Catalog, Nature medicine 2020, PMID:32042192. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Sex hormone-binding globulin levels (rs1005421). MyGeneLog™. https://www.mygenelog.com/variants/rs1005421

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