0 826Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others6Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 2,031 Han Chinese ancestry cases, 2,044 Han Chinese ancestry controls; replicated in 3,986 Han Chinese ancestry cases, 4,157 Han Chinese ancestry controls.
The effect
Each copy of the C allele carried 1.49 times the odds of Esophageal cancer (95% confidence interval 1.37-1.61); p = 2 × 10−19.
How common The C allele had a frequency of about 78% in the people studied.
Where it sits Chromosome 5, band 5q11.2 — in an intron of PDE4D.
What each result means
A/ANo copy of the version the research linked to Esophageal cancer. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Esophageal cancer. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Esophageal cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs10052657 is a single position in the genome, in or near the PDE4D gene. Published research associates it with esophageal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10052657 linked to?
On MyGeneLog this position is linked to Oesophageal Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs10052657 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10052657 come from?
GWAS Catalog, Nature genetics 2011, PMID:21642993. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 826Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others6Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Esophageal cancer (rs10052657). MyGeneLog™. https://www.mygenelog.com/variants/rs10052657