Who was studied 9,069 European ancestry cases, 1,550 East Asian ancestry cases, 13,578 European ancestry controls, 1,567 East Asian ancestry controls.
The effect
Each copy of the A allele carried 1.20 times the odds of Ankylosing spondylitis (95% confidence interval -); p = 6 × 10−14.
How common The A allele had a frequency of about 73% in the people studied.
Where it sits Chromosome 5, band 5q15 — in an intron of ERAP1.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Ankylosing spondylitis compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Ankylosing spondylitis.
G/GPublished research associates this genotype with typical/baseline likelihood of Ankylosing spondylitis — no copies of the reported risk allele.
rs10045403 is a single position in the genome, in or near the ERAP2 gene. Published research associates it with ankylosing spondylitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10045403 linked to?
On MyGeneLog this position is linked to Ankylosing Spondylitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs10045403 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10045403 come from?
GWAS Catalog, Nat Genet 2013, PMID:23749187. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.