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Gestational diabetes

CAST · rs10036439

Where this position leads

Condition: Gestational Diabetes Mellitus

rs10036439 Condition: Gestational Diabetes Mellitus Gestational Diabetes Mellitus Condition rs10036439 rs10036439 CAST

What the study found

Who was studied 29,640 European ancestry female cases, 736,610 European ancestry female controls, 3,921 South Asian ancestry female cases, 14,233 South Asian ancestry female controls, 4,346 East Asian ancestry female cases, 23,286 East Asian ancestry female controls, 244 Hispanic or Latin American female cases, 744 Hispanic or Latin American female controls, 154 African American or Afro-Caribbean female cases, 1,272 African American or Afro-Caribbean female controls.

The effect The reported allele is G; the catalogue records no effect size ; p = 9 × 10−42.

How common The G allele had a frequency of about 70% in the people studied.

Where it sits Chromosome 5, band 5q15 — in an intron of CAST.

What each result means

C/C No copy of the version the research linked to Gestational diabetes. This is the starting point the study compared everyone against.
C/G One copy of the version the research linked to Gestational diabetes. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Gestational diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects
Brito Nunes C, Rukins V, Cisse AH, White F, McBride N, Kuang A, Allard C, Ronkainen J, Hughes A, Elliott A, Thorleifsson G, Vaudel M
and 67 more — show all
Laisk T, Gu Y, Lamri A, Chen L, Tuhkanen J, Lahti J, Calas L, Muntaner M, Karhunen V, Choi J, Heiskala A, Hatem G, Fragoso-Bargas N, Rifas-Shiman SL, Paz-Lopez G, Stinson SE, Bhowmik B, Ahlqvist E, Deleuze JF, Eriksson JG, Park J, Teo K, Räikkönen K, Stefansson K, Molina-Vega M, Subbarao P, Beaumont RN, Johansson S, Tuomi T, Hansen T, Engelbrechtsen L, Morcillo S, Oken E, Quigstad E, Birkeland KI, Vääräsmäki M, Hattersley AT, Sebert S, Hitman GA, Kwak SH, Järvelin MR, Prasad RB, Heude B, Meirhaeghe A, Bouchard L, Jacques PÉ, Laivuori H, Tan KH, Anand SS, van Heel DA, Liu S, Njølstad PR, Steinthorsdottir V, Widén E, Keikkala E, Scholtens DM, Lowe WL, Finer S, Morris AP, Mägi R, Zöllner J, Borges MC, Lawlor DA, Hivert MF, Freathy RM, Evans DM, Moen GH
Estonian Biobank Research Team · Genes & Health Research Team
Nature communications · 2026 · PMID 42225636 · open access

Questions about rs10036439

What is rs10036439?

rs10036439 is a single position in the genome, in or near the CAST gene. Published research associates it with gestational diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10036439 linked to?

On MyGeneLog this position is linked to Gestational Diabetes Mellitus. The research behind each link, and its sources, are set out on that condition page.

Does having rs10036439 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10036439 come from?

GWAS Catalog, Nature communications 2026, PMID:42225636. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gestational diabetes (rs10036439). MyGeneLog™. https://www.mygenelog.com/variants/rs10036439

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