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Worry

LINC02503 · rs10034259

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 348,219 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0187 lower (95% confidence interval 0.013-0.025); p = 4 × 10⁻¹⁰.

Where it sits Chromosome 4, band 4q24 — in an intron of LINC02503.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Worry — no copies of the reported risk allele.

A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Worry.

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Worry compared to the general population.

Source

Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways

Nagel M, Jansen PR, Stringer S, Watanabe K, de Leeuw CA, Bryois J, Savage JE, Hammerschlag AR, Skene NG, Muñoz-Manchado AB, White T, Tiemeier H

and 6 more — show all

Linnarsson S, Hjerling-Leffler J, Polderman TJC, Sullivan PF, van der Sluis S, Posthuma D

23andMe Research Team

Nature genetics · 2018 · PMID 29942085

Questions about rs10034259

What is rs10034259?

rs10034259 is a single position in the genome, in or near the LINC02503 gene. Published research associates it with worry. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10034259 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10034259 come from?

GWAS Catalog, Nature genetics 2018, PMID:29942085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Worry (rs10034259). MyGeneLog™. https://www.mygenelog.com/variants/rs10034259

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