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Its strongest genetic-study result is p = 10−16, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 5,201 European ancestry cases, 9,066 European ancestry controls; replicated in 2,018 European ancestry cases, 6,925 European ancestry controls.
The effect
Each copy of the G allele carried 1.20 times the odds of Systemic lupus erythematosus (95% confidence interval 1.15–1.25); p = 4 × 10−17.
Where it sits Chromosome 4, band 4q24 — in an intron of BANK1.
What each result means
A/ANo copy of the version the research linked to Systemic lupus erythematosus. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Systemic lupus erythematosus. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Systemic lupus erythematosus. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2015 · PMID 26502338 · open access
Questions about rs10028805
What is rs10028805?
rs10028805 is a single position in the genome, in or near the BANK1 gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10028805 linked to?
On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.
Does having rs10028805 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10028805 come from?
GWAS Catalog, Nat Genet 2015, PMID:26502338. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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