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Hodgkin's lymphoma

OLIG3 · rs1002658

Where this position leads

Condition: Hodgkin Lymphoma

rs1002658 Condition: Hodgkin Lymphoma Hodgkin Lymphoma Condition rs1002658 rs1002658 OLIG3

What the study found

Who was studied 5,325 European ancestry cases, 22,425 European ancestry controls.

The effect Each copy of the T allele carried 1.19 times the odds of Hodgkin's lymphoma (95% confidence interval 1.12-1.26); p = 3 × 10−8.

How common The T allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 6, band 6q23.3 — inside LINC03004.

What each result means

C/C No copy of the version the research linked to Hodgkin's lymphoma. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Hodgkin's lymphoma. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Hodgkin's lymphoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1002658

What is rs1002658?

rs1002658 is a single position in the genome, in or near the OLIG3 gene. Published research associates it with hodgkin's lymphoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1002658 linked to?

On MyGeneLog this position is linked to Hodgkin Lymphoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs1002658 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1002658 come from?

GWAS Catalog, Blood 2018, PMID:30194254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Hodgkin's lymphoma (rs1002658). MyGeneLog™. https://www.mygenelog.com/variants/rs1002658

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