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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 26,122 European ancestry cases, 461,431 European ancestry controls, 9,305 East Asian ancestry cases, 168,253 East Asian ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0479 lower (95% confidence interval 0.031-0.065); p = 2 × 10−8.
Where it sits Chromosome 4, band 4p14 — between genes, 0.2 kb from LIAS.
What each result means
A/ATwo copies of the version the research linked to Cholelithiasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Cholelithiasis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Cholelithiasis. This is the starting point the study compared everyone against.
rs10025454 is a single position in the genome, in or near the near LIAS gene. Published research associates it with cholelithiasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs10025454 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10025454 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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