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Asthma

ADAD1 · rs10021288

Where this position leads

Condition: Asthma

rs10021288 Condition: Asthma Asthma Condition rs10021288 rs10021288 ADAD1

What the study found

Who was studied 46,802 European ancestry cases, 347,481 European ancestry controls; replicated in 23,948 European and unknown ancestry cases, 118,538 European and unknown ancestry controls.

The effect Each copy of the A allele carried 1.06 times the odds of Asthma (95% confidence interval 1.04-1.07); p = 4 × 10−15.

How common The A allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 4, band 4q27 — between genes, 3.1 kb from RN7SL335P.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Asthma compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Asthma.
G/G Published research associates this genotype with typical/baseline likelihood of Asthma — no copies of the reported risk allele.
Source
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis
Zhu Z, Zhu X, Liu CL, Shi H, Shen S, Yang Y, Hasegawa K, Camargo CA Jr, Liang L
The European respiratory journal · 2019 · PMID 31619474

Questions about rs10021288

What is rs10021288?

rs10021288 is a single position in the genome, in or near the ADAD1 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10021288 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs10021288 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10021288 come from?

GWAS Catalog, The European respiratory journal 2019, PMID:31619474. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs10021288). MyGeneLog™. https://www.mygenelog.com/variants/rs10021288

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