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Who was studied 315,133 European ancestry individuals, 74,970 East Asian ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0181 lower (95% confidence interval 0.013-0.023); p = 6 × 10−12.
Where it sits Chromosome 22, band 22q12.2 — in the 3′ untranslated region of SEC14L6.
What each result means
A/ANo copy of the version the research linked to HDL cholesterol. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to HDL cholesterol. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to HDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs1001409 is a single position in the genome, in or near the SEC14L6 gene. Published research associates it with hdl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1001409 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs1001409 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1001409 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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