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Who was studied 310,368 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 6.35 z-score higher; p = 2 × 10−10.
How common The T allele had a frequency of about 53% in the people studied.
Where it sits Chromosome 4, band 4q31.21 — in an intron of ZNF827.
What each result means
G/GNo copy of the version the research linked to Coronary artery disease (MTAG). This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Coronary artery disease (MTAG). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Coronary artery disease (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
NPJ genomic medicine · 2025 · PMID 41022758 · open access
Questions about rs10006310
What is rs10006310?
rs10006310 is a single position in the genome, in or near the ZNF827 gene. Published research associates it with coronary artery disease (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10006310 linked to?
On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs10006310 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10006310 come from?
GWAS Catalog, NPJ genomic medicine 2025, PMID:41022758. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 111226Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others6Total11Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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