Phosphorus (phosphate)

The association is established; acting on it is not advised

74 positions in the genome linked to how much phosphate is in the blood. They explain part of why levels differ between people; they do not say what to take.

What this supplement connects to

What this page holds

74 positions in the genome that published studies have linked to how much phosphate is in the blood, from 5 studies. The genes named most often: ENPP3, DYRK4, ENPP1, GRK6, FGF23, ABCC6.

What it means, and what it does not

These positions explain part of why two people eating the same food can have different phosphate levels. They do not say whether anyone should take Phosphorus (phosphate), or how much. A blood level is measured by a test, and no guideline sets a dose from a gene result.

This is for learning, not medical advice. Ask a doctor or pharmacist before starting a supplement, especially alongside other medicines.

Sources

Papers, with their authors

Genetics of 35 blood and urine biomarkers in the UK Biobank

Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP

and 11 more — show all

Qian J, Shcherbina A, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA

FinnGen

Nature genetics · 2021 · PMID 33462484 · open access

A scalable variational inference approach for increased mixed-model association power

Loya H, Kalantzis G, Cooper F, Palamara PF

Nature genetics · 2025 · PMID 39789286 · open access

Genetic architecture of routinely acquired blood tests in a British South Asian cohort

Jacobs BM, Stow D, Hodgson S, Zöllner J, Samuel M, Kanoni S, Bidi S, Walter K, Langenberg C, Dobson R, Finer S, Morton C

and 5 more — show all

Siddiqui MK, Martin HC, Pietzner M, Mathur R, van Heel DA

Genes & Health Research Team

Nature communications · 2024 · PMID 39414775 · open access

Rare and common genetic determinants of metabolic individuality and their effects on human health

Surendran P, Stewart ID, Au Yeung VPW, Pietzner M, Raffler J, Wörheide MA, Li C, Smith RF, Wittemans LBL, Bomba L, Menni C, Zierer J

and 24 more — show all

Nature medicine · 2022 · PMID 36357675 · open access

Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases

Chen Y, Lu T, Pettersson-Kymmer U, Stewart ID, Butler-Laporte G, Nakanishi T, Cerani A, Liang KYH, Yoshiji S, Willett JDS, Su CY, Raina P

and 7 more — show all

Greenwood CMT, Farjoun Y, Forgetta V, Langenberg C, Zhou S, Ohlsson C, Richards JB

Nature genetics · 2023 · PMID 36635386

Official information

How much to take, what too much does and what it interacts with — the questions a gene does not answer — are on the government pages below.

Questions about Phosphorus (phosphate)

What is Phosphorus (phosphate)?

Phosphorus (phosphate) is sold as a dietary supplement (mineral). This page lists the 74 positions in the genome that research has linked to its blood level.

Do my genes decide my phosphate level?

Partly. 74 positions from 5 studies are linked to it, each with a small effect; diet, health and medicines matter too. A blood test measures the level itself.

Should I take Phosphorus (phosphate) because of a gene result?

No guideline sets a supplement or a dose from these positions. Decide with a doctor or pharmacist, from a measured level where one is relevant.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Phosphorus (phosphate). MyGeneLog™. https://www.mygenelog.com/supplements/phosphorus

Nothing on this page recommends taking anything. If a result here matters to you, take it to a doctor or a pharmacist rather than to a shop.