Glycine

The association is established; acting on it is not advised

72 positions in the genome linked to how much glycine is in the blood. They explain part of why levels differ between people; they do not say what to take.

What this supplement connects to

What this page holds

72 positions in the genome that published studies have linked to how much glycine is in the blood, from 11 studies. The genes named most often: PKD1L2, CPS1, ALDH1L1, MAP2, ERBB4, GCSH.

What it means, and what it does not

These positions explain part of why two people eating the same food can have different glycine levels. They do not say whether anyone should take Glycine, or how much. A blood level is measured by a test, and no guideline sets a dose from a gene result.

This is for learning, not medical advice. Ask a doctor or pharmacist before starting a supplement, especially alongside other medicines.

Sources

Papers, with their authors

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation

Richardson TG, Leyden GM, Wang Q, Bell JA, Elsworth B, Davey Smith G, Holmes MV

PLoS biology · 2022 · PMID 35213538 · open access

Assessing the causal association of glycine with risk of cardio-metabolic diseases

Wittemans LBL, Lotta LA, Oliver-Williams C, Stewart ID, Surendran P, Karthikeyan S, Day FR, Koulman A, Imamura F, Zeng L, Erdmann J, Schunkert H

and 11 more — show all

Khaw KT, Griffin JL, Forouhi NG, Scott RA, Wood AM, Burgess S, Howson JMM, Danesh J, Wareham NJ, Butterworth AS, Langenberg C

Nature communications · 2019 · PMID 30837465 · open access

Unravelling genetic architecture of circulatory amino acid levels, and their effect on risk of complex disorders

Abar L, Zuber V, Otto GW, Tzoulaki I, Dehghan A

NAR genomics and bioinformatics · 2024 · PMID 38711861 · open access

Decreased Circulating Very Small Low-Density Lipoprotein is Likely Causal for Age-Related Macular Degeneration

Farashi S, Bonelli R, Jackson VE, Ansell BRE, Guymer RH, Bahlo M

Ophthalmology science · 2024 · PMID 39091897 · open access

Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease

Jia Q, Han Y, Huang P, Woodward NC, Gukasyan J, Kettunen J, Ala-Korpela M, Anufrieva O, Wang Q, Perola M, Raitakari O, Lehtimäki T

and 11 more — show all

Viikari J, Järvelin MR, Boehnke M, Laakso M, Mohlke KL, Fiehn O, Wang Z, Tang WHW, Hazen SL, Hartiala JA, Allayee H

Journal of the American Heart Association · 2019 · PMID 31070104 · open access

Official information

How much to take, what too much does and what it interacts with — the questions a gene does not answer — are on the government pages below.

Read the labels — NIH Dietary Supplement Label Database, US product labels that list "glycine"

Questions about Glycine

What is Glycine?

Glycine is sold as a dietary supplement (amino acid). This page lists the 72 positions in the genome that research has linked to its blood level.

Do my genes decide my glycine level?

Partly. 72 positions from 11 studies are linked to it, each with a small effect; diet, health and medicines matter too. A blood test measures the level itself.

Should I take Glycine because of a gene result?

No guideline sets a supplement or a dose from these positions. Decide with a doctor or pharmacist, from a measured level where one is relevant.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Glycine. MyGeneLog™. https://www.mygenelog.com/supplements/glycine

Nothing on this page recommends taking anything. If a result here matters to you, take it to a doctor or a pharmacist rather than to a shop.