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Sensitive

Multiple sclerosis

near GALC · rs8007714

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−19, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 688 Japanese ancestry cases, 205,199 Japanese ancestry controls, 27,572 European ancestry cases, 1,436,801 European ancestry controls, 819 African ancestry cases, 155,904 African ancestry controls, 295 American ancestry ancestry cases, 45,659 American ancestry ancestry controls.

The effect Each copy of the T allele carried 0.84 times the odds of Multiple sclerosis (95% confidence interval 0.81-0.87); p = 6 × 10−20.

How common each version is

CT
Korean KRGDB
C 82.0% · T 18.0%
Korean Korea4K
C 83.9% · T 16.1%
Korean Korea1K
C 84.3% · T 15.7%
Japanese ToMMo
C 85.3% · T 14.7%
Vietnamese
C 75.7% · T 24.3%
World gnomAD
C 90.5% · T 9.5%
World 1000 Genomes
C 89.2% · T 10.8%
World TOPMed
C 90.2% · T 9.8%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Multiple sclerosis. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Multiple sclerosis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Multiple sclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics
Fujimoto R, Ogawa K, Namba S, Ogawa Y, Edahiro R, Sonehara K, Tagawa S, Watanabe M, Yata T, Shirai Y, Yamamoto Y, Sato G
and 21 more — show all
Kai C, Naito T, Hosokawa A, Yamamoto M, Matsuda K, Shimizu F, Kinoshita M, Mihara M, Nakamori M, Shimizu Y, Kawachi I, Miyamoto K, Niino M, Kumanogoh A, Nakatsuji Y, Matsushita T, Mochizuki H, Kira JI, Okuno T, Isobe N, Okada Y
Japan MS/NMOSD Biobank · BioBank Japan Project
Nature genetics · 2026 · PMID 42706308 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Multiple sclerosis (rs8007714). MyGeneLog™. https://www.mygenelog.com/variants/rs8007714

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