Sensitive

Renal cell carcinoma

MET · rs766401668

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

There is no record yet to score this position by (a ClinVar disease classification or a genome-wide significant study). That is not the same as weak evidence.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Benign/Likely benign for Renal cell carcinoma, Hereditary cancer-predisposing syndrome, Papillary renal cell carcinoma type 1; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2025-04-21. ClinVar record 1161076 NM_000245.4(MET):c.2055G>A (p.Gly685=)

Classification Conflicting classifications of pathogenicity for Renal cell carcinoma, Papillary renal cell carcinoma type 1; criteria provided, conflicting classifications (1 of 4 stars, 2 submitters), last evaluated 2025-02-25. ClinVar record 938024 NM_000245.4(MET):c.2055G>T (p.Gly685=)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-11-09 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

G/G No copy of the version labs disagree about for Renal cell carcinoma: in ClinVar, some labs call it disease-causing and others do not. This is the usual result. (ClinVar VCV000938024, criteria provided, conflicting classifications)

G/T One copy of the version labs disagree about for Renal cell carcinoma: in ClinVar, some labs call it disease-causing and others do not, so what one copy means is not settled. A genetic counsellor can look at the separate records. (ClinVar VCV000938024, criteria provided, conflicting classifications)

T/T Two copies of the version labs disagree about for Renal cell carcinoma: in ClinVar, some labs call it disease-causing and others do not. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. (ClinVar VCV000938024, criteria provided, conflicting classifications)

Source: ClinVar VCV000938024, criteria provided, conflicting classifications

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Renal cell carcinoma (rs766401668). MyGeneLog™. https://www.mygenelog.com/variants/rs766401668

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