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Gamma glutamyl transferase levels

RORA · rs76263497

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−23, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 342,339 European ancestry individuals, 6,015 African ancestry individuals, 7,336 South Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0332 higher (95% confidence interval 0.027-0.04); p = 2 × 10−23.

Where it sits Chromosome 15, band 15q22.2 — in an intron of RORA.

How common each version is

AG
Korean Korea1K
A 0.1% · G 100.0%
World gnomAD
A 9.9% · G 90.1%
World 1000 Genomes
A 4.4% · G 95.6%
World TOPMed
A 9.1% · G 90.9%

By ancestry gnomAD

East Asian
G 99.9%
European (non-Finnish)
A 15.4% · G 84.6%
African / African American
A 2.6% · G 97.4%
South Asian
A 2.3% · G 97.7%
Admixed American (Latino)
A 7.7% · G 92.3%
Middle Eastern
A 1.7% · G 98.3%
Finnish
A 15.7% · G 84.3%
Ashkenazi Jewish
A 8.4% · G 91.6%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

A/A Two copies of the version the research linked to Gamma glutamyl transferase levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Gamma glutamyl transferase levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Gamma glutamyl transferase levels. This is the starting point the study compared everyone against.
Source
Genetics of 35 blood and urine biomarkers in the UK Biobank
Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP
and 11 more — show all
Qian J, Shcherbina A, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA
FinnGen
Nature genetics · 2021 · PMID 33462484 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Gamma glutamyl transferase levels (rs76263497). MyGeneLog™. https://www.mygenelog.com/variants/rs76263497

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